Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma.
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ABSTRACT:
SUBMITTER: Pan H
PROVIDER: S-EPMC5300227 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma.
Pan Hao H Gu Liqun L Liu Binjie B Li Yiping Y Wang Yuehong Y Bai Xinna X Li Long L Wang Baisheng B Peng Qian Q Yao Zhigang Z Tang Zhangui Z
PloS one 20170209 2
It is widely accepted that oral squamous cell carcinoma (OSCC) is a major contributor to the incidence and mortality of neck and head cancer. Tropomyosin-1 (TPM1), which is expressed at a low level, has been considered a prominent tumor-suppressing gene in a variety of solid tumors, although the precise mechanism of the TPM1 gene in OSCC progression remains unknown. We found that TPM1 expression levels decreased in OSCC patients and OSCC cell lines. The overall and cancer-specific survival of pa ...[more]
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