Ontology highlight
ABSTRACT:
SUBMITTER: Nicastro G
PROVIDER: S-EPMC5300891 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nicastro Giuseppe G Candel Adela M AM Uhl Michael M Oregioni Alain A Hollingworth David D Backofen Rolf R Martin Stephen R SR Ramos Andres A
Cell reports 20170101 5
Zipcode binding protein 1 (ZBP1) is an oncofetal RNA-binding protein that mediates the transport and local translation of β-actin mRNA by the KH3-KH4 di-domain, which is essential for neuronal development. The high-resolution structures of KH3-KH4 with their respective target sequences show that KH4 recognizes a non-canonical GGA sequence via an enlarged and dynamic hydrophobic groove, whereas KH3 binding to a core CA sequence occurs with low specificity. A data-informed kinetic simulation of th ...[more]