Ontology highlight
ABSTRACT:
SUBMITTER: Yeon JH
PROVIDER: S-EPMC5301195 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Yeon Ju Hun JH Mazinani Nima N Schlappi Travis S TS Chan Karen Y T KY Baylis James R JR Smith Stephanie A SA Donovan Alexander J AJ Kudela Damien D Stucky Galen D GD Liu Ying Y Morrissey James H JH Kastrup Christian J CJ
Scientific reports 20170210
Short-chain polyphosphate (polyP) is released from platelets upon platelet activation, but it is not clear if it contributes to thrombosis. PolyP has increased propensity to clot blood with increased polymer length and when localized onto particles, but it is unknown whether spatial localization of short-chain polyP can accelerate clotting of flowing blood. Here, numerical simulations predicted the effect of localization of polyP on clotting under flow, and this was tested in vitro using microfl ...[more]