Ontology highlight
ABSTRACT:
SUBMITTER: Montanari F
PROVIDER: S-EPMC5302078 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Montanari Floriane F Cseke Anna A Wlcek Katrin K Ecker Gerhard F GF
SLAS discovery : advancing life sciences R & D 20160711 1
The breast cancer resistance protein (BCRP) is an ABC transporter playing a crucial role in the pharmacokinetics of drugs. The early identification of substrates and inhibitors of this efflux transporter can help to prevent or foresee drug-drug interactions. In this work, we built a ligand-based in silico classification model to predict the inhibitory potential of drugs toward BCRP. The model was applied as a virtual screening technique to identify potential inhibitors among the small-molecules ...[more]