Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy.
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ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC5302479 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy.
Chen Zhihang Z Krishnamachary Balaji B Bhujwalla Zaver M ZM
Nanomaterials (Basel, Switzerland) 20160222 2
Although small interfering RNA (siRNA) therapy has proven to be a specific and effective treatment in cells, the delivery of siRNA is a challenge for the applications of siRNA therapy. We present a degradable dextran with amine groups as an siRNA nano-carrier. In our nano-carrier, the amine groups are conjugated to the dextran platform through the acetal bonds, which are acid sensitive. Therefore this siRNA carrier is stable in neutral and basic conditions, while the amine groups can be cleaved ...[more]
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