Ontology highlight
ABSTRACT:
SUBMITTER: Arita T
PROVIDER: S-EPMC5302957 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Arita Tomohiro T Ichikawa Daisuke D Konishi Hirotaka H Komatsu Shuhei S Shiozaki Atsushi A Ogino Shinpei S Fujita Yuji Y Hiramoto Hidekazu H Hamada Junichi J Shoda Katsutoshi K Kosuga Toshiyuki T Fujiwara Hitoshi H Okamoto Kazuma K Otsuji Eigo E
Oncotarget 20160801 35
<h4>Background</h4>Peritoneal metastasis consists of a highly complex series of steps, and the details of the underlying molecular mechanism remain largely unclear. In this study, the effects of tumor-derived exosomes (TEX) on the progression of gastric cancers were investigated in peritoneal metastasis.<h4>Results</h4>TEX were internalized in both mesothelial and gastric cancer cells in a cellular origin non-specific manner. Internalization of TEX into mesothelial cells promoted significant adh ...[more]