Unknown

Dataset Information

0

Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants.


ABSTRACT: Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. Animal studies have demonstrated that in utero BPA exposure leads to increased adult body weight. Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay utilizing derivatization with pentafluorobenzyl followed by analysis with LC-ECAPCI-MS/MS with a limit of detection of 0.08ng/mL and limit of quantification (LOQ) of 0.25ng/mL. The mean BW of infants with AF BPA 0.40-2.0ng/mL was 241.8g less than infants with AF BPA less than the LOQ after controlling for covariates (p=0.049). No effect was seen outside this range indicating a non-monotonic effect. Our data suggest that low level BPA exposure in utero decreases BW and needs further study.

SUBMITTER: Pinney SE 

PROVIDER: S-EPMC5303174 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants.

Pinney Sara E SE   Mesaros Clementina A CA   Snyder Nathaniel W NW   Busch Christine M CM   Xiao Rui R   Aijaz Sara S   Ijaz Naila N   Blair Ian A IA   Manson Jeanne M JM  

Reproductive toxicology (Elmsford, N.Y.) 20161106


Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. Animal studies have demonstrated that in utero BPA exposure leads to increased adult body weight. Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay utilizing derivatization with pentafluorobenzy  ...[more]

Similar Datasets

| S-EPMC10072248 | biostudies-literature
| S-EPMC10222006 | biostudies-literature
| S-EPMC8971495 | biostudies-literature
| S-EPMC10672859 | biostudies-literature
| S-EPMC4261245 | biostudies-literature
| S-EPMC5490606 | biostudies-literature
| S-EPMC5569895 | biostudies-literature
2023-07-05 | GSE206696 | GEO
| S-EPMC5011160 | biostudies-literature
| S-EPMC4553339 | biostudies-literature