Ontology highlight
ABSTRACT:
SUBMITTER: Trella KJ
PROVIDER: S-EPMC5303683 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Trella Katie J KJ Li Jun J Stylianou Eleni E Wang Vincent M VM Frank Jonathan M JM Galante Jorge J Sandy John D JD Plaas Anna A Wysocki Robert R
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20160829 5
We have used a murine Achilles tendinopathy model to investigate whether tissue changes (such as collagen disorganization, chondroid metaplasia, and loss of tensile properties) which are broadly characteristic of human tendinopathies, are accompanied by changes in the expression of chromatin-modifying enzymes and the methylation status of promoter regions of tendon cell DNA. Tendinopathy was induced by two intra-tendinous TGF-β1 injections followed by cage activity or treadmill running for up to ...[more]