Ontology highlight
ABSTRACT:
SUBMITTER: Wu T
PROVIDER: S-EPMC5303822 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Wu Tongde T Huang Julianne J Moore Patrick J PJ Little Michael S MS Walton William G WG Fellner Robert C RC Alexis Neil E NE Peter Di Y Y Redinbo Matthew R MR Tilley Stephen L SL Tarran Robert R
Nature communications 20170206
Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family member A1, BPIFA1, is a secreted innate defence protein. Here we show that BPIFA1 levels are reduced in sputum samples from asthmatic patients and that BPIFA1 is secreted basolaterally from healthy, but not asthmatic human bronchial epithelial cultures (HBECs), where it suppresses ASM contractility by binding to and inhibiting t ...[more]