Rapid development of a DNA vaccine for Zika virus.
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ABSTRACT:
SUBMITTER: Dowd KA
PROVIDER: S-EPMC5304212 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Rapid development of a DNA vaccine for Zika virus.
Dowd Kimberly A KA Ko Sung-Youl SY Morabito Kaitlyn M KM Yang Eun Sung ES Pelc Rebecca S RS DeMaso Christina R CR Castilho Leda R LR Abbink Peter P Boyd Michael M Nityanandam Ramya R Gordon David N DN Gallagher John Robert JR Chen Xuejun X Todd John-Paul JP Tsybovsky Yaroslav Y Harris Audray A Huang Yan-Jang S YS Higgs Stephen S Vanlandingham Dana L DL Andersen Hanne H Lewis Mark G MG De La Barrera Rafael R Eckels Kenneth H KH Jarman Richard G RG Nason Martha C MC Barouch Dan H DH Roederer Mario M Kong Wing-Pui WP Mascola John R JR Pierson Theodore C TC Graham Barney S BS
Science (New York, N.Y.) 20160922 6309
Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of childbearing age and their partners is imperative. We found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after Z ...[more]
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