Novel 18F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging.
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ABSTRACT:
SUBMITTER: Ji AY
PROVIDER: S-EPMC5304286 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Novel <sup>18</sup>F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging.
Ji Ai-Yan AY Jin Qiao-Mei QM Zhang Dong-Jian DJ Zhu Hua H Su Chang C Duan Xing-Hua XH Bian Li L Sun Zi-Ping ZP Ni Yi-Cheng YC Zhang Jian J Yang Zhi Z Yin Zhi-Qi ZQ
ACS medicinal chemistry letters 20161228 2
Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel <sup>18</sup>F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [<sup>18</sup>F]FA3OP emerged as the most promising compound with best stability and ...[more]
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