Ontology highlight
ABSTRACT:
SUBMITTER: Giordanetto F
PROVIDER: S-EPMC5304308 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Giordanetto Fabrizio F Tyrchan Christian C Ulander Johan J
ACS medicinal chemistry letters 20170118 2
Design strategies centered on intramolecular hydrogen bonds are sometime used in drug discovery, but their general applicability has not been addressed beyond scattered examples or circumstantial evidence. A total of 1053 matched molecular pairs where only one of the two molecules is able to form an intramolecular hydrogen bond via monatomic transformations have been identified across the ChEMBL database. These pairs were used to investigate the effect of intramolecular hydrogen bonds on biologi ...[more]