Ontology highlight
ABSTRACT:
SUBMITTER: Hospital MA
PROVIDER: S-EPMC5304990 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hospital Marie-Anne MA Green Alexa S AS Maciel Thiago T TT Moura Ivan C IC Leung Anskar Y AY Bouscary Didier D Tamburini Jerome J
OncoTargets and therapy 20170203
Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy that is cured in as few as 15%-40% of cases. Tremendous improvements in AML prognostication arose from a comprehensive analysis of leukemia cell genomes. Among normal karyotype AML cases, mutations in the <i>FLT3</i> gene are the ones most commonly detected as having a deleterious prognostic impact. FLT3 is a transmembrane tyrosine kinase receptor, and alterations of the FLT3 gene such as internal tandem duplications (FLT3-IT ...[more]