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Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis.


ABSTRACT:

Aims/hypothesis

Disparities in HbA1c levels have been observed among ethnic groups. Most studies were performed in patients with diabetes mellitus (DM), which may interfere with results due to the high variability of glucose levels. We conducted a systematic review and meta-analysis to investigate the effect of ethnicity on HbA1c levels in individuals without DM.

Methods

This is a systematic review with meta-analysis. We searched MEDLINE and EMBASE up to September 2016. Studies published after 1996, performed in adults without DM, reporting HbA1c results measured by certified/standardized methods were included. A random effects model was used and the effect size was presented as weighted HbA1c mean difference (95% CI) between different ethnicities as compared to White ethnicity.

Results

Twelve studies met the inclusion criteria, totalling data from 49,238 individuals. There were significant differences between HbA1c levels in Blacks [0.26% (2.8 mmol/mol); 95% CI 0.18 to 0.33 (2.0 to 3.6), p <0.001; I2 = 90%, p <0.001], Asians [0.24% (2.6 mmol/mol); 95% CI 0.16 to 0.33 (1.7 to 3.6), p <0.001; I2 = 80%, p = 0.0006] and Latinos [0.08% (0.9 mmol/mol); IC 95% 0.06 to 0.10 (0.7 to 1.1); p <0.001; I2 = 0%; p = 0.72] when compared to Whites.

Conclusions/interpretation

This meta-analysis shows that, in individuals without DM, HbA1c values are higher in Blacks, Asians, and Latinos when compared to White persons. Although small, these differences might have impact on the use of a sole HbA1c point to diagnose DM in all ethnic populations.

SUBMITTER: Cavagnolli G 

PROVIDER: S-EPMC5305058 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis.

Cavagnolli Gabriela G   Pimentel Ana Laura AL   Freitas Priscila Aparecida Correa PA   Gross Jorge Luiz JL   Camargo Joíza Lins JL  

PloS one 20170213 2


<h4>Aims/hypothesis</h4>Disparities in HbA1c levels have been observed among ethnic groups. Most studies were performed in patients with diabetes mellitus (DM), which may interfere with results due to the high variability of glucose levels. We conducted a systematic review and meta-analysis to investigate the effect of ethnicity on HbA1c levels in individuals without DM.<h4>Methods</h4>This is a systematic review with meta-analysis. We searched MEDLINE and EMBASE up to September 2016. Studies pu  ...[more]

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