Dataset Information

Increased risk of dementia in patients hospitalized with acute kidney injury: A nationwide population-based cohort study.

ABSTRACT:

Purpose

To determine whether acute kidney injury (AKI) is a risk factor for dementia.

Methods

This nationwide population-based cohort study was based on data from the Taiwan National Health Insurance Research Database for 2000-2011. The incidence and relative risk of dementia were assessed in 207788 patients hospitalized for AKI. The comparison control was selected using the propensity score based on age, sex, index year and comorbidities.

Results

During the 12-year follow-up, patients with AKI had a significantly higher incidence for developing dementia than did the controls (8.84 vs 5.75 per 1000 person-y). A 1.88-fold increased risk of dementia (95% confidence interval, 1.76-2.01) was observed after adjustment for age, sex, and several comorbidities (diabetes, hypertension, hyperlipidemia, head injury, depression, stroke, chronic obstructive pulmonary disease, coronary artery disease, congestive heart failure, atrial fibrillation, cancer, liver disease, chronic infection/inflammation, autoimmune disease, malnutrition).

Conclusions

We found that patients with AKI exhibited a significantly increased risk of developing dementia. This study provides evidence on the association between AKI and long-term adverse outcomes. Additional clinical studies investigating the related pathways are warranted.

SUBMITTER: Tsai HH

PROVIDER: S-EPMC5305096 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Increased risk of dementia in patients hospitalized with acute kidney injury: A nationwide population-based cohort study.

Tsai Hsin-Hsi HH Yen Ruoh-Fang RF Lin Cheng-Li CL Kao Chia-Hung CH

PloS one 20170213 2

<h4>Purpose</h4>To determine whether acute kidney injury (AKI) is a risk factor for dementia.<h4>Methods</h4>This nationwide population-based cohort study was based on data from the Taiwan National Health Insurance Research Database for 2000-2011. The incidence and relative risk of dementia were assessed in 207788 patients hospitalized for AKI. The comparison control was selected using the propensity score based on age, sex, index year and comorbidities.<h4>Results</h4>During the 12-year follow- ...[more]

PMID: 28192452

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Project description:PURPOSE:The association between primary headaches, including tension-type headache (TTH) as one of the most common primary headache disorders, and dementia remains controversial. In this nationwide, population-based, retrospective, cohort study, we explored the potential association between TTH and dementia and examined sex, age, and comorbidities as risk factors for dementia. METHODS:Using the Taiwan National Health Insurance Research Database (NHIRD) claims data, the sample included 13908 subjects aged ?20 years with newly-diagnosed TTH in 2000-2006. The non-TTH group included 55632 randomly selected sex- and age-matched TTH-free individuals. All subjects were followed until dementia diagnosis, death, or the end of 2011. Patients with dementia, including vascular and non-vascular (including Alzheimer's) subtypes, were identified using International Classification of Diseases Ninth Revision, Clinical Modification codes. Multivariate Cox proportional hazards regression models were used to assess the risk of dementia and dementia-associated risk factors, such as migraine and other medical comorbidities. RESULTS:During the average follow-up of 8.14 years, the incidence density rates of dementia were 5.30 and 3.68/1,000 person-years in the TTH and non-TTH groups, respectively. Compared with the non-TTH group, the risks of dementia were 1.25 (95% confidence interval [CI], 1.11-1.42) and 1.13 (95% CI, 1.01-1.27) times higher in the women and >65-year-old TTH group, respectively. TTH patients with comorbidities had a higher risk of dementia. TTH patients had a greater risk of non-vascular dementia (hazard ratio, 1.21; 95% CI, 1.09-1.34) than the non-TTH group. CONCLUSION:TTH patients have a future risk of dementia, indicating a potentially linked disease pathophysiology that warrants further study. The association between TTH and dementia is greater in women, older adults, and with comorbidities. Clinicians should be aware of potential dementia comorbidity in TTH patients.

Dataset Information

Increased risk of dementia in patients hospitalized with acute kidney injury: A nationwide population-based cohort study.

Purpose

Methods

Results

Conclusions

Publications

Increased risk of dementia in patients hospitalized with acute kidney injury: A nationwide population-based cohort study.

Similar Datasets

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