Ontology highlight
ABSTRACT:
SUBMITTER: Fitzgerald GA
PROVIDER: S-EPMC5305207 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Fitzgerald Gabriel A GA Mulligan Christopher C Mindell Joseph A JA
eLife 20170125
The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints on the transporter's mechanism. Stoichiometry is known for a wide array of mammalian transporters, but, due to a lack of readily available tools, not for most of the prokaryotic transporters for which high-resolution structures are available. Here, we d ...[more]