Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.
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ABSTRACT:
SUBMITTER: Taylor KC
PROVIDER: S-EPMC5305565 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Regulation of KCNQ/Kv7 family voltage-gated K<sup>+</sup> channels by lipids.
Taylor Keenan C KC Sanders Charles R CR
Biochimica et biophysica acta. Biomembranes 20161104 4
Many years of studies have established that lipids can impact membrane protein structure and function through bulk membrane effects, by direct but transient annular interactions with the bilayer-exposed surface of protein transmembrane domains, and by specific binding to protein sites. Here, we focus on how phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>) and polyunsaturated fatty acids (PUFAs) impact ion channel function and how the structural details of the interactions of these lipids ...[more]
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