Influence of A-21T and C-262T genetic polymorphisms at the promoter region of the catalase (CAT) on gene expression.

ABSTRACT:

Objective

Catalase (CAT, OMIM: 115500) is one of the major antioxidant enzymes, which plays an important role in the clearance of reactive oxygen species. Three genetic polymorphisms of A-21T (rs7943316), C-262T (rs1001179), and C-844T (rs769214) in the promoter region of the CAT have been reported. It has been suggested that these polymorphisms may alter the recognition sites of transcriptional factors, therefore it might be concluded that these polymorphisms may alter the expression levels of the gene. The aim of the present study is to evaluate the associations between these genetic variations and the CAT mRNA levels in human peripheral blood cells.

Methods

The present study consisted of 47 healthy students of Shiraz University (south-west Iran). Genotypes of the CAT poly

SUBMITTER: Saify K 

PROVIDER: S-EPMC5305992 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature