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ABSTRACT: Objectives
Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with 15O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR).Methods
51 patients (63 (61-65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 underwent PET and 47 ICA/FFR. Obstructive CAD was defined as CTCA stenosis >50 % and CTP hypoperfusion, ICA stenosis >70 % or FFR <0.80.Results
PET hyperaemic myocardial blood flow (MBF) was lower in obstructive than non-obstructive territories defined by ICA/FFR (1.76 (1.32-2.20) vs 3.11 (2.44-3.79) mL/(g/min), P?ConclusionCT myocardial attenuation density correlates with 15O-water PET MBF. CTCA and CTP can accurately identify obstructive CAD.Key points
•CT myocardial perfusion can aid the assessment of suspected coronary artery disease. • CT attenuation density from "snapshot" imaging is a marker of myocardial perfusion. • CT myocardial attenuation density correlates with 15 O-water PET myocardial blood flow. • CT attenuation density is lower in obstructive territories defined by invasive angiography. • Diagnostic accuracy of CTCA+CTP is comparable to invasive angiography + fractional flow reserve.
SUBMITTER: Williams MC
PROVIDER: S-EPMC5306314 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Williams Michelle C MC Mirsadraee Saeed S Dweck Marc R MR Weir Nicholas W NW Fletcher Alison A Lucatelli Christophe C MacGillivray Tom T Golay Saroj K SK Cruden Nicholas L NL Henriksen Peter A PA Uren Neal N McKillop Graham G Lima João A C JA Reid John H JH van Beek Edwin J R EJ Patel Dilip D Newby David E DE
European radiology 20160622 3
<h4>Objectives</h4>Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with <sup>15</sup>O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR).<h4>Methods</h4>51 patients (63 (61-65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 u ...[more]