Ontology highlight
ABSTRACT:
SUBMITTER: Morieri ML
PROVIDER: S-EPMC5307001 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Morieri Mario Luca ML Passaro Angelina A Zuliani Giovanni G
Mediators of inflammation 20170131
Inflammation plays a major role in the onset of cardiovascular disease (CVD). Interleukine-6 (IL-6) is a multifunctional cytokine involved both in the beneficial acute inflammatory response and in the detrimental chronic low-grade systemic inflammation. Large genetic human studies, using Mendelian randomization approaches, have clearly showed that IL-6 pathway is causally involved in the onset of myocardial infarction. At the same time, IL-6 pathway is divided into two arms: classic signaling (e ...[more]