Preterm Delivery and Maternal Cardiovascular Disease in Young and Middle-Aged Adult Women.

ABSTRACT:

Background

Preterm delivery has been shown to be associated with increased risk of cardiovascular disease (CVD), but it is unknown whether this risk remains after adjustment for prepregnancy lifestyle and CVD risk factors.

Methods

We examined the association between history of having delivered an infant preterm (<37 weeks) and CVD in 70 182 parous women in the Nurses' Health Study II. Multivariable Cox proportional-hazards models were used to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) for CVD events (myocardial infarction and stroke, n=949); we also adjusted for intermediates to determine the proportion of the association between preterm and CVD accounted for by postpartum development of CVD risk factors.

Results

After adjusting for age, race, pa

SUBMITTER: Tanz LJ 

PROVIDER: S-EPMC5308562 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature