Ontology highlight
ABSTRACT:
SUBMITTER: Skalamera D
PROVIDER: S-EPMC5308632 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Škalamera Dubravka D Dahmer-Heath Mareike M Stevenson Alexander J AJ Pinto Cletus C Shah Esha T ET Daignault Sheena M SM Said Nur Akmarina B M NA Davis Melissa M Haass Nikolas K NK Williams Elizabeth D ED Hollier Brett G BG Thompson Erik W EW Gabrielli Brian B Gonda Thomas J TJ
Oncotarget 20160901 38
Epithelial to mesenchymal transition (EMT) is a developmental program that has been implicated in progression, metastasis and therapeutic resistance of some carcinomas. To identify genes whose overexpression drives EMT, we screened a lentiviral expression library of 17000 human open reading frames (ORFs) using high-content imaging to quantitate cytoplasmic vimentin. Hits capable of increasing vimentin in the mammary carcinoma-derived cell line MDA-MB-468 were confirmed in the non-tumorigenic bre ...[more]