Ontology highlight
ABSTRACT:
SUBMITTER: Qin L
PROVIDER: S-EPMC5308636 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Oncotarget 20160901 38
Emerging studies suggest that dominant peripheral tolerance is a major mechanism of immune escape in disseminated leukemia. Using an established murine acute myeloid leukemia (AML) model, we here show that systemic administration of recombinant IL-33 dramatically inhibits the leukemia growth and prolongs the survival of leukemia-bearing mice in a CD8+ T cell dependent manner. Exogenous IL-33 treatment enhanced anti-leukemia activity by increasing the expansion and IFN-γ production of leukemia-re ...[more]