Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto K
PROVIDER: S-EPMC5308665 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Yamamoto Keisuke K Tateishi Keisuke K Kudo Yotaro Y Hoshikawa Mayumi M Tanaka Mariko M Nakatsuka Takuma T Fujiwara Hiroaki H Miyabayashi Koji K Takahashi Ryota R Tanaka Yasuo Y Ijichi Hideaki H Nakai Yousuke Y Isayama Hiroyuki H Morishita Yasuyuki Y Aoki Taku T Sakamoto Yoshihiro Y Hasegawa Kiyoshi K Kokudo Norihiro N Fukayama Masashi M Koike Kazuhiko K
Oncotarget 20160901 38
Inhibitors of bromodomain and extraterminal domain (BET) proteins, a family of chromatin reader proteins, have therapeutic efficacy against various malignancies. However, the detailed mechanisms underlying the anti-tumor effects in distinct tumor types remain elusive. Here, we show a novel antitumor mechanism of BET inhibition in pancreatic ductal adenocarcinoma (PDAC). We found that JQ1, a BET inhibitor, decreased desmoplastic stroma, a hallmark of PDAC, and suppressed the growth of patient-der ...[more]