Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5308689 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Oncotarget 20160901 38
A meta-analysis of animal models was conducted to evaluate the prophylactic effects of mesenchymal stem cells (MSCs) on acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation. A total of 50 studies involving 1848 animals were included. The pooled results showed that MSCs significantly reduced aGVHD-associated mortality (risk ratio = 0.70, 95% confidence interval 0.62 to 0.79, P = 2.73×10-9) and clinical scores (standardized mean difference = -3.60, 95% c ...[more]