Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed K
PROVIDER: S-EPMC5308691 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Ahmed Khalil K Kren Betsy T BT Abedin Md Joynal MJ Vogel Rachel I RI Shaughnessy Daniel P DP Nacusi Lucas L Korman Vicci L VL Li Yingming Y Dehm Scott M SM Zimmerman Cheryl L CL Niehans Gloria A GA Unger Gretchen M GM Trembley Janeen H JH
Oncotarget 20160901 38
CK2, a protein serine/threonine kinase, promotes cell proliferation and suppresses cell death. This essential-for-survival signal demonstrates elevated expression and activity in all cancers examined, and is considered an attractive target for cancer therapy. Here, we present data on the efficacy of a tenfibgen (TBG) coated nanocapsule which delivers its cargo of siRNA (siCK2) or single stranded RNA/DNA oligomers (RNAi-CK2) simultaneously targeting CK2α and α' catalytic subunits. Intravenous adm ...[more]