Ontology highlight
ABSTRACT:
SUBMITTER: de Souza JG
PROVIDER: S-EPMC5308724 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
de Souza Jean Gabriel JG Morais Katia L.P. KL Anglés-Cano Eduardo E Boufleur Pamela P de Mello Evandro Sobroza ES Maria Durvanei Augusto DA Origassa Clarice Silvia Taemi CS de Campos Zampolli Hamilton H Câmara Niels Olsen Saraiva NO Berra Carolina Maria CM Bosch Rosemary Viola RV Chudzinski-Tavassi Ana Marisa AM
Oncotarget 20160901 38
Renal cell carcinoma (RCC), also called kidney cancer or renal adenocarcinoma, is highly resistant to current treatments. It has been previously reported that a Kunitz-type inhibitor domain-containing protein, isolated from the salivary glands of the Amblyomma cajennense tick, triggers apoptosis in murine renal adenocarcinoma cells (Renca) by inhibiting the proteasome and endoplasmic reticulum stress. Of note, Amblyomin-X is the corresponding recombinant protein identified in the cDNA library fr ...[more]