Ontology highlight
ABSTRACT:
SUBMITTER: Johansson P
PROVIDER: S-EPMC5308752 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Johansson Patricia P Klein-Hitpass Ludger L Grabellus Florian F Arnold Georg G Klapper Wolfram W Pförtner Roman R Dührsen Ulrich U Eckstein Anja A Dürig Jan J Küppers Ralf R
Oncotarget 20160901 38
The pathogenesis of ocular adnexal marginal zone lymphomas of mucosa-associated lymphatic tissue-type (OAML) is still poorly understood. We analyzed 63 cases of such lymphomas for non-synonymous mutations in 24 candidate genes by amplicon sequencing. We validated frequent mutations in the NF-κB regulators MYD88, TNFAIP3 and TNIP1 in OAML, but also identified recurrent mutations in several additional components of the NF-κB pathway, including BCL10 and NFKBIA. Overall, 60% of cases had mutations ...[more]