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Antibiotics, birth mode, and diet shape microbiome maturation during early life.

ABSTRACT: Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered ?-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.

SUBMITTER: Bokulich NA

PROVIDER: S-EPMC5308924 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Antibiotics, birth mode, and diet shape microbiome maturation during early life.

Bokulich Nicholas A NA Chung Jennifer J Battaglia Thomas T Henderson Nora N Jay Melanie M Li Huilin H D Lieber Arnon A Wu Fen F Perez-Perez Guillermo I GI Chen Yu Y Schweizer William W Zheng Xuhui X Contreras Monica M Dominguez-Bello Maria Gloria MG Blaser Martin J MJ

Science translational medicine 20160601 343

Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to ...[more]

PMID: 27306664

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