Antibiotics, birth mode, and diet shape microbiome maturation during early life.
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ABSTRACT:
SUBMITTER: Bokulich NA
PROVIDER: S-EPMC5308924 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Antibiotics, birth mode, and diet shape microbiome maturation during early life.
Bokulich Nicholas A NA Chung Jennifer J Battaglia Thomas T Henderson Nora N Jay Melanie M Li Huilin H D Lieber Arnon A Wu Fen F Perez-Perez Guillermo I GI Chen Yu Y Schweizer William W Zheng Xuhui X Contreras Monica M Dominguez-Bello Maria Gloria MG Blaser Martin J MJ
Science translational medicine 20160601 343
Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to ...[more]
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