Ontology highlight
ABSTRACT:
SUBMITTER: Lee SY
PROVIDER: S-EPMC5309242 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lee Sang-Yong SY Sarkar Soumya S Bhattarai Sanjay S Namasivayam Vigneshwaran V De Jonghe Steven S Stephan Holger H Herdewijn Piet P El-Tayeb Ali A Müller Christa E CE
Frontiers in pharmacology 20170215
Nucleotide pyrophosphatase/phosphodiesterase type 1 (NPP1) is a membrane glycoprotein involved in the hydrolysis of extracellular nucleotides. Its major substrate is ATP which is converted to AMP and diphosphate. NPP1 was proposed as a new therapeutic target in brain cancer and immuno-oncology. Several NPP1 inhibitors have been reported to date, most of which were evaluated vs. the artificial substrate <i>p</i>-nitrophenyl 5'-thymidine monophosphate (<i>p</i>-Nph-5'-TMP). Recently, we observed l ...[more]