Ontology highlight
ABSTRACT:
SUBMITTER: Tyagi RK
PROVIDER: S-EPMC5309771 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Tyagi Rajeev K RK Miles Brodie B Parmar Rajesh R Garg Neeraj K NK Dalai Sarat K SK Baban Babak B Cutler Christopher W CW
Scientific reports 20170215
Targeting of myeloid-dendritic cell receptor DC-SIGN by numerous chronic infectious agents, including Porphyromonas gingivalis, is shown to drive-differentiation of monocytes into dysfunctional mDCs. These mDCs exhibit alterations of their fine-tuned homeostatic function and contribute to dysregulated immune-responses. Here, we utilize P. gingivalis mutant strains to show that pathogen-differentiated mDCs from primary human-monocytes display anti-apoptotic profile, exhibited by elevated phosphor ...[more]