Ontology highlight
ABSTRACT:
SUBMITTER: Smith N
PROVIDER: S-EPMC5309800 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Smith Nikaïa N Pietrancosta Nicolas N Davidson Sophia S Dutrieux Jacques J Chauveau Lise L Cutolo Pasquale P Dy Michel M Scott-Algara Daniel D Manoury Bénédicte B Zirafi Onofrio O McCort-Tranchepain Isabelle I Durroux Thierry T Bachelerie Françoise F Schwartz Olivier O Münch Jan J Wack Andreas A Nisole Sébastien S Herbeuval Jean-Philippe JP
Nature communications 20170209
Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate ...[more]