Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals.
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ABSTRACT:
SUBMITTER: Sun B
PROVIDER: S-EPMC5310690 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals.
Sun Bo B Taha Maie S MS Ramsey Benjamin B Torregrosa-Allen Sandra S Elzey Bennett D BD Yeo Yoon Y
Journal of controlled release : official journal of the Controlled Release Society 20160526
Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of ovarian cancer, but the full potential is yet to be realized. To facilitate IP chemotherapy of ovarian cancer, we developed an in-situ crosslinkable hydrogel depot containing paclitaxel (PTX) nanocrystals (PNC). PNC suppressed SKOV3 cell proliferation more efficiently than microparticulate PTX precipitates (PPT), and the gel containing PNC (PNC-gel) showed a lower maximum tolerated dose than PPT-containing gel (PPT-gel) in ...[more]
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