Influence of cerebral blood vessel movements on the position of perivascular synapses.
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ABSTRACT:
SUBMITTER: Urrecha M
PROVIDER: S-EPMC5310786 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Influence of cerebral blood vessel movements on the position of perivascular synapses.
Urrecha Miguel M Romero Ignacio I DeFelipe Javier J Merchán-Pérez Angel A
PloS one 20170215 2
Synaptic activity is regulated and limited by blood flow, which is controlled by blood vessel dilation and contraction. Traditionally, the study of neurovascular coupling has mainly focused on energy consumption and oxygen delivery. However, the mechanical changes that blood vessel movements induce in the surrounding tissue have not been considered. We have modeled the mechanical changes that movements of blood vessels cause in neighboring synapses. Our simulations indicate that synaptic densiti ...[more]
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