Dataset Information

Estimating the OncotypeDX score: validation of an inexpensive estimation tool.

ABSTRACT: OncotypeDX, a multi-gene expression assay, has been incorporated into clinical practice as a prognostic and predictive tool. However, its use in resource-constrained international healthcare systems is limited. Here we develop and validate a simplified model using clinicopathologic criteria to predict OncotypeDX score.Patients with estrogen receptor (ER) and/or progesterone receptor (PR)-positive and HER2-negative invasive ductal carcinoma for whom the OncotypeDX test was successfully performed between 09/2008 and 12/2011 were retrospectively identified. Tumor size, nuclear and histologic grade, lymphovascular invasion, and ER and PR status were extracted from pathology reports. Data were split into a training dataset comprising women tested 09/2008-04/2011, and a validation dataset comprising women tested 04/2011-12/2011. Using the training dataset, linear regression analysis was used to identify factors associated with OncotypeDX score, and to create a simplified risk score and identify risk cutoffs.Estrogen and progesterone receptors, tumor size, nuclear and histologic grades, and lymphovascular involvement were independently associated with OncotypeDX. The full model explained 39% of the variation in the test data, and the simplified risk score and cutoffs assigned 57% of patients in the test data to the correct risk category (OncotypeDX score <18, 18-30, >30). 41% of patients were predicted to have OncotypeDX score <18, of these 83, 16, and 2% had true scores of <18, 18-30, and >30, respectively.Awaiting an inexpensive test that is prognostic and predictive, our simplified tool allows clinicians to identify a fairly large group of patients (41%) with very low chance of having high-risk disease (2%).

SUBMITTER: Eaton AA

PROVIDER: S-EPMC5310948 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Estimating the OncotypeDX score: validation of an inexpensive estimation tool.

Eaton Anne A AA Pesce Catherine E CE Murphy James O JO Stempel Michelle M MM Patil Sujata M SM Brogi Edi E Hudis Clifford A CA El-Tamer Mahmoud M

Breast cancer research and treatment 20161207 3

<h4>Background</h4>OncotypeDX, a multi-gene expression assay, has been incorporated into clinical practice as a prognostic and predictive tool. However, its use in resource-constrained international healthcare systems is limited. Here we develop and validate a simplified model using clinicopathologic criteria to predict OncotypeDX score.<h4>Methods</h4>Patients with estrogen receptor (ER) and/or progesterone receptor (PR)-positive and HER2-negative invasive ductal carcinoma for whom the Oncotype ...[more]

PMID: 27928699

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Estimating the OncotypeDX score: validation of an inexpensive estimation tool.

Publications

Estimating the OncotypeDX score: validation of an inexpensive estimation tool.

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