Ontology highlight
ABSTRACT:
SUBMITTER: Porter EB
PROVIDER: S-EPMC5310984 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Porter Ely B EB Polaski Jacob T JT Morck Makenna M MM Batey Robert T RT
Nature chemical biology 20170116 3
Allosteric RNA devices are increasingly being viewed as important tools capable of monitoring enzyme evolution, optimizing engineered metabolic pathways, facilitating gene discovery and regulators of nucleic acid-based therapeutics. A key bottleneck in the development of these platforms is the availability of small-molecule-binding RNA aptamers that robustly function in the cellular environment. Although aptamers can be raised against nearly any desired target through in vitro selection, many ca ...[more]