Ontology highlight
ABSTRACT:
SUBMITTER: Crawford DC
PROVIDER: S-EPMC5311059 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Nature communications 20170210
Recent studies suggest that stimulus-evoked and spontaneous neurotransmitter release processes are mechanistically distinct. Here we targeted the non-canonical synaptic vesicle SNAREs Vps10p-tail-interactor-1a (vti1a) and vesicle-associated membrane protein 7 (VAMP7) to specifically inhibit spontaneous release events and probe whether these events signal independently of evoked release to the postsynaptic neuron. We found that loss of vti1a and VAMP7 impairs spontaneous high-frequency glutamate ...[more]