Ontology highlight
ABSTRACT:
SUBMITTER: Charpentier M
PROVIDER: S-EPMC5312342 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Charpentier Maud M Croyal Mikael M Carbonnelle Delphine D Fortun Agnès A Florenceau Laetitia L Rabu Catherine C Krempf Michel M Labarrière Nathalie N Lang François F
Oncotarget 20160901 37
MELOE-1 and MELOE-2, two highly specific melanoma antigens involved in T cell immunosurveillance are produced by IRES-dependent translation of the long « non coding » and polycistronic RNA, meloe. In the present study, we document the expression of an additional ORF, MELOE-3, located in the 5' region of meloe. Data from in vitro translation experiments and transfection of melanoma cells with bicistronic vectors documented that MELOE-3 is exclusively translated by the classical cap-dependent path ...[more]