Ontology highlight
ABSTRACT:
SUBMITTER: Rivas JR
PROVIDER: S-EPMC5312707 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Rivas Jacqueline R JR Ireland Sara J SJ Chkheidze Rati R Rounds William H WH Lim Joseph J Johnson Jordan J Ramirez Denise M O DM Ligocki Ann J AJ Chen Ding D Guzman Alyssa A AA Woodhall Mark M Wilson Patrick C PC Meffre Eric E White Charles C Greenberg Benjamin M BM Waters Patrick P Cowell Lindsay G LG Stowe Ann M AM Monson Nancy L NL
Acta neuropathologica 20161011 1
Plasmablasts are a highly differentiated, antibody secreting B cell subset whose prevalence correlates with disease activity in Multiple Sclerosis (MS). For most patients experiencing partial transverse myelitis (PTM), plasmablasts are elevated in the blood at the first clinical presentation of disease (known as a clinically isolated syndrome or CIS). In this study we found that many of these peripheral plasmablasts are autoreactive and recognize primarily gray matter targets in brain tissue. Th ...[more]