Ontology highlight
ABSTRACT:
SUBMITTER: Nixon BR
PROVIDER: S-EPMC5313062 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Nixon Benjamin R BR Williams Alexandra F AF Glennon Michael S MS de Feria Alejandro E AE Sebag Sara C SC Baldwin H Scott HS Becker Jason R JR
JCI insight 20170223 4
It remains unclear how perturbations in cardiomyocyte sarcomere function alter postnatal heart development. We utilized murine models that allowed manipulation of cardiac myosin-binding protein C (MYBPC3) expression at critical stages of cardiac ontogeny to study the response of the postnatal heart to disrupted sarcomere function. We discovered that the hyperplastic to hypertrophic transition phase of mammalian heart development was altered in mice lacking MYBPC3 and this was the critical period ...[more]