Ontology highlight
ABSTRACT:
SUBMITTER: Kaneko MK
PROVIDER: S-EPMC5313638 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kaneko Mika K MK Nakamura Takuro T Honma Ryusuke R Ogasawara Satoshi S Fujii Yuki Y Abe Shinji S Takagi Michiaki M Harada Hiroyuki H Suzuki Hiroyoshi H Nishioka Yasuhiko Y Kato Yukinari Y
Cancer medicine 20170119 2
Human podoplanin (hPDPN), which binds to C-type lectin-like receptor-2 (CLEC-2), is involved in platelet aggregation and cancer metastasis. The expression of hPDPN in cancer cells or cancer-associated fibroblasts indicates poor prognosis. Human lymphatic endothelial cells, lung-type I alveolar cells, and renal glomerular epithelial cells express hPDPN. Although numerous monoclonal antibodies (mAbs) against hPDPN are available, they recognize peptide epitopes of hPDPN. Here, we generated a novel ...[more]