Ontology highlight
ABSTRACT:
SUBMITTER: Xiao X
PROVIDER: S-EPMC5314887 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Xiao Xingqing X Hung Michelle E ME Leonard Joshua N JN Hall Carol K CK
Journal of computational chemistry 20160804 27
Our previously developed peptide-design algorithm was improved by adding an energy minimization strategy which allows the amino acid sidechains to move in a broad configuration space during sequence evolution. In this work, the new algorithm was used to generate a library of 21-mer peptides which could substitute for λ N peptide in binding to boxB RNA. Six potential peptides were obtained from the algorithm, all of which exhibited good binding capability with boxB RNA. Atomistic molecular dynami ...[more]