Ontology highlight
ABSTRACT:
SUBMITTER: Most J
PROVIDER: S-EPMC5315691 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Most Jasper J Tosti Valeria V Redman Leanne M LM Fontana Luigi L
Ageing research reviews 20160817
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate nutrition, has been shown to extend healthspan and lifespan in rodent and primate models. Accumulating data from observational and randomized clinical trials indicate that CR in humans results in some of the same metabolic and molecular adaptations that have been shown to improve health and retard the accumulation of molecular damage in animal models of longevity. In particular, moderate CR in humans ...[more]