Ontology highlight
ABSTRACT:
SUBMITTER: Ishikawa K
PROVIDER: S-EPMC5316350 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ishikawa Ken K Medina Scott H SH Schneider Joel P JP Klar Amar J S AJS
Cell chemical biology 20170112 2
Although resistance toward small-molecule chemotherapeutics has been well studied, the potential of tumor cells to avoid destruction by membrane-lytic compounds remains unexplored. Anticancer peptides (ACPs) are a class of such agents that disrupt tumor cell membranes through rapid and non-stereospecific mechanisms, encouraging the perception that cellular resistance toward ACPs is unlikely to occur. We demonstrate that eukaryotic cells can, indeed, develop resistance to the model oncolytic pept ...[more]