Dataset Information

Saphenous vein graft near-infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near-infrared spectroscopy (ORACLE-NIRS) registry.

ABSTRACT: OBJECTIVES:We sought to examine near-infrared spectroscopy (NIRS) imaging findings of aortocoronary saphenous vein grafts (SVGs). BACKGROUND:SVGs are prone to develop atherosclerosis similar to native coronary arteries. They have received little study using NIRS. METHODS:We examined the clinical characteristics and imaging findings from 43 patients who underwent NIRS imaging of 45 SVGs at our institution between 2009 and 2016. RESULTS:The mean patient age was 67?±?7 years and 98% were men, with high prevalence of diabetes mellitus (56%), hypertension (95%), and dyslipidemia (95%). Mean SVG age was 7?±?7 years, mean SVG lipid core burden index (LCBI) was 53?±?60 and mean maxLCBI4 mm was 194?±?234. Twelve SVGs (27%) had lipid core plaques (2 yellow blocks on the block chemogram), with a higher prevalence in SVGs older than 5 years (46% vs. 5%, P?=?0.002). Older SVG age was associated with higher LCBI (r?=?0.480, P?

SUBMITTER: Danek BA

PROVIDER: S-EPMC5316385 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Saphenous vein graft near-infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near-infrared spectroscopy (ORACLE-NIRS) registry.

Danek Barbara A BA Karatasakis Aris A Alame Aya J AJ Nguyen-Trong Phuong-Khanh J PJ Karacsonyi Judit J Rangan Bavana B Roesle Michele M Atwell Amy A Resendes Erica E Martinez-Parachini Jose Roberto JR Iwnetu Rahel R Kalsaria Pratik P Siddiqui Furqan F Muller James E JE Banerjee Subhash S Brilakis Emmanouil E

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20160818 6

<h4>Objectives</h4>We sought to examine near-infrared spectroscopy (NIRS) imaging findings of aortocoronary saphenous vein grafts (SVGs).<h4>Background</h4>SVGs are prone to develop atherosclerosis similar to native coronary arteries. They have received little study using NIRS.<h4>Methods</h4>We examined the clinical characteristics and imaging findings from 43 patients who underwent NIRS imaging of 45 SVGs at our institution between 2009 and 2016.<h4>Results</h4>The mean patient age was 67 ± 7 ...[more]

PMID: 27535486

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Project description:IntroductionAneurysmal subarachnoid haemorrhage (aSAH) is a devastating disease associated with high mortality and morbidity. The main threat to patients is delayed cerebral ischaemia (DCI). Near-infrared spectroscopy (NIRS) is a recent technology allowing continuous, non-invasive cerebral oximetry that could permit timely detection of impending DCI and appropriate intervention to improve outcomes. However, the ability of regional oxygen saturation to detect DCI, its association to the outcome, or benefits of any interventions based on NIRS data, are lacking. Our aims are to evaluate NIRS technology both as a therapeutic tool to improve outcomes in aSAH patients and as a diagnostic tool for DCI.Methods and analysisMEDLINE, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews will be searched from their inception and without language restriction. Our search strategy will cover the themes of subarachnoid haemorrhage and cerebral oximetry, without limitations regarding studied outcomes. We will identify all observational and interventional human studies of adult patients hospitalised after aSAH that were monitored using NIRS. Functional outcome measures, including the modified Rankin Scale, the Glasgow Outcome Scale and the Barthel Index, will constitute the primary outcome. The Cochrane Risk of Bias tool will be used for randomised controlled trials, the ROBINS-I tool to assess non-randomised studies of interventions and the Newcastle-Ottawa Scale for cohort or case-control studies. The Quality Assessment of Diagnostic Accuracy Studies-2 will be applied to studies evaluating NIRS diagnostic accuracy for DCI. We will evaluate the quality of the evidence of the effect based on the Grading of Recommendations Assessment, Development and Evaluation methodology.Ethics and disseminationDissemination will proceed through submission for journal publication, trial registry completion and abstract presentation. Ethics approval is not required.Prospero registration numberCRD42020077522.

Dataset Information

Saphenous vein graft near-infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near-infrared spectroscopy (ORACLE-NIRS) registry.

Publications

Saphenous vein graft near-infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near-infrared spectroscopy (ORACLE-NIRS) registry.

Similar Datasets

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