Ontology highlight
ABSTRACT:
SUBMITTER: Juszkiewicz S
PROVIDER: S-EPMC5316413 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Juszkiewicz Szymon S Hegde Ramanujan S RS
Molecular cell 20170105 4
Diverse cellular stressors have been observed to trigger site-specific ubiquitination on several ribosomal proteins. However, the ubiquitin ligases, biochemical consequences, and physiologic pathways linked to these modifications are not known. Here, we show in mammalian cells that the ubiquitin ligase ZNF598 is required for ribosomes to terminally stall during translation of poly(A) sequences. ZNF598-mediated stalling initiated the ribosome-associated quality control (RQC) pathway for degradati ...[more]