Unknown

Dataset Information

0

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder in obese individuals. Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed in the liver. Here we demonstrate that targeted disruption of Ant2 in mouse liver enhances uncoupled respiration without damaging mitochondrial integrity and liver functions. Interestingly, liver specific Ant2 knockout mice are leaner and resistant to hepatic steatosis, obesity and insulin resistance under a lipogenic diet. Protection against fatty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside, a specific inhibitor of ANT. Targeted manipulation of hepatic mitochondrial metabolism, particularly through inhibition of ANT, may represent an alternative approach in NAFLD and obesity treatment.

SUBMITTER: Cho J 

PROVIDER: S-EPMC5316896 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder in obese individuals. Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed in the liver. Here we demonstrate that targeted disruption of Ant2 in mouse liver enhances uncoupled respiration without damaging mitochondrial integrity and liver functions. Interestingly, liver specific Ant2 knockout mice are leaner and resistant to hepatic st  ...[more]

Similar Datasets

Unknown Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance.
| S-EPMC3365775 | biostudies-literature
Unknown Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis.
| S-EPMC9947060 | biostudies-literature
Unknown FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats.
| S-EPMC2842143 | biostudies-literature
Transcriptomics Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis
2023-06-15 | E-MTAB-12920 | biostudies-arrayexpress
Unknown Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice.
| S-EPMC3736732 | biostudies-other
Unknown Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
| S-EPMC4532771 | biostudies-literature
Unknown Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance.
| S-EPMC2809951 | biostudies-literature
Unknown NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism.
| S-EPMC6894049 | biostudies-literature
Unknown Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis.
| S-EPMC4913705 | biostudies-literature
Unknown Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance.
| S-EPMC5860441 | biostudies-literature