Ontology highlight
ABSTRACT:
SUBMITTER: Kaschner M
PROVIDER: S-EPMC5316958 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kaschner Marco M Schillinger Oliver O Fettweiss Timo T Nutschel Christina C Krause Frank F Fulton Alexander A Strodel Birgit B Stadler Andreas A Jaeger Karl-Erich KE Krauss Ulrich U
Scientific reports 20170220
Allostery, i.e. the control of enzyme activity by a small molecule at a location distant from the enzyme's active site, represents a mechanism essential for sustaining life. The rational design of allostery is a non-trivial task but can be achieved by fusion of a sensory domain, which responds to environmental stimuli with a change in its structure. Hereby, the site of domain fusion is difficult to predict. We here explore the possibility to rationally engineer allostery into the naturally not a ...[more]