Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis.
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ABSTRACT:
SUBMITTER: Jakubczyk D
PROVIDER: S-EPMC5317212 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis.
Jakubczyk Dorota D Caputi Lorenzo L Stevenson Clare E M CE Lawson David M DM O'Connor Sarah E SE
Chemical communications (Cambridge, England) 20161201 99
Aj_EasH is a non-heme iron- and α-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 Å resolution) reported here provides insight into the mechanism of this unusual and complex reaction. ...[more]
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