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IL-15R? deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.

ABSTRACT: The purpose of this study was to determine mitochondrial changes in fast muscles from interleukin-15 receptor alpha knockout (IL-15R?KO) mice. We tested the hypothesis that fast muscles from IL-15R?KO mice would have a greater mitochondrial density and altered internal structure compared to muscles from control mice. In fast muscles from IL-15R?KO mice, mitochondrial density was 48% greater with a corresponding increase in mitochondrial DNA content. Although there were no differences in the relative size of isolated mitochondria, internal complexity was lower in mitochondria from IL-15R?KO mice. These data support an increase in mitochondrial biogenesis and provide direct evidence for a greater density and altered internal structure of mitochondria in EDL muscles deficient in IL-15R?.

SUBMITTER: Pistilli EE

PROVIDER: S-EPMC5317336 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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IL-15Rα deficiency leads to mitochondrial and myofiber differences in fast mouse muscles.

Pistilli Emidio E EE Guo Ge G Stauber William T WT

Cytokine 20121030 1

The purpose of this study was to determine mitochondrial changes in fast muscles from interleukin-15 receptor alpha knockout (IL-15RαKO) mice. We tested the hypothesis that fast muscles from IL-15RαKO mice would have a greater mitochondrial density and altered internal structure compared to muscles from control mice. In fast muscles from IL-15RαKO mice, mitochondrial density was 48% greater with a corresponding increase in mitochondrial DNA content. Although there were no differences in the rela ...[more]

PMID: 23116661

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